阿米替林对大鼠脑中神经元谷氨酸转运体rEAAC1 mRNA表达的调节作用。

Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline.

作者信息

Andin Josefine, Stenfors Carina, Ross Svante B, Marcusson Jan

机构信息

Department of Neuroscience and Locomotion, Division of Geriatric Medicine, Linköpings Universitet, Kliniskt forskningscenter/Clinical Research Centre, Linköping University Hospital, SE-581 85, Linköping, Sweden.

出版信息

Brain Res Mol Brain Res. 2004 Jul 5;126(1):74-7. doi: 10.1016/j.molbrainres.2004.03.023.

DOI:10.1016/j.molbrainres.2004.03.023

PMID:15207918

Abstract

Glutamate transporters regulate the glutamate concentration in the synaptic cleft within the CNS, a regulation required for normal brain function. In several neurological conditions, the amount of glutamate is altered. One reason for the changes in glutamate concentration might be impaired glutamate transporter function. In this study, an in situ hybridisation technique has been used to elucidate changes in mRNA expression of the glutamate transporter, excitatory amino acid carrier 1 (EAAC1), after treatment with the tricyclic antidepressant (TCA) amitriptyline. The results lead to the suggestion that treatment with tricyclic antidepressants leads to changes in the EAAC1 mRNA expression in rat brain suggesting involvement of the glutamate system in the tricyclic treatment of depression.

摘要

谷氨酸转运体调节中枢神经系统突触间隙中的谷氨酸浓度，这是正常脑功能所必需的调节。在几种神经疾病中，谷氨酸的量会发生改变。谷氨酸浓度变化的一个原因可能是谷氨酸转运体功能受损。在本研究中，采用原位杂交技术来阐明用三环类抗抑郁药（TCA）阿米替林治疗后谷氨酸转运体兴奋性氨基酸载体1（EAAC1）的mRNA表达变化。结果表明，三环类抗抑郁药治疗导致大鼠脑内EAAC1 mRNA表达发生变化，提示谷氨酸系统参与了三环类药物治疗抑郁症的过程。