Mirat Jure, Raguz Miroslav, Romić Zeljko, Bergovec Mijo, Raos Vjekoslava, Sikić-Vagić Jozica, Bergovec Marko
Zavod za bolesti srca i krvnih zila, Opća bolnica Sveti Duh, 10000 Zagreb, Hrvatska.
Acta Med Croatica. 2004;58(2):115-7.
Inflammation is a component of atherosclerotic plaque, but it is also a possible pathogenetic factor of acute coronary event responsible for coronary instability. Inflammatory markers are considered as new risk factors for atherosclerosis. Among others (C-reactive protein (CRP) is the best known marker of inflammatory response which is most frequently found in patients with acute myocardial infarction preceded by a period of instability. High values of inflammatory markers indicate poor prognosis after acute myocardial infarction. Therapy may lower the inflammatory component and the risk of coronary disease. Specific response of inflammatory marker during diagnostic and percutaneous coronary interventions indicates more severe coronary disease.
炎症是动脉粥样硬化斑块的一个组成部分,但它也是导致冠状动脉不稳定的急性冠状动脉事件的一个可能致病因素。炎症标志物被视为动脉粥样硬化的新危险因素。其中,C反应蛋白(CRP)是最广为人知的炎症反应标志物,在经历一段不稳定期后发生急性心肌梗死的患者中最为常见。炎症标志物的高值表明急性心肌梗死后预后不良。治疗可能会降低炎症成分和冠心病风险。在诊断和经皮冠状动脉介入治疗期间炎症标志物的特异性反应表明冠状动脉疾病更为严重。