Goldberg J A, Scott R N, Davidson P M, Murray G D, Stallard S, George W D, Maguire G P
Western Infirmary, Glasgow, UK.
Eur J Surg Oncol. 1992 Aug;18(4):327-31.
In this prospective study, the psychological morbidity associated with the treatment of breast cancer was assessed. The study population comprised all patients referred to one centre with a recently diagnosed breast lump, who were to undergo surgery. Psychological morbidity was assessed preoperatively and at 6 and 12 months postoperatively by modified Rotterdam Symptom Checklist. Three hundred and twenty patients completed all three questionnaires: 93 women undergoing mastectomy, 73 women having conservation therapy for breast cancer and 156 women having biopsy for benign breast disease. Patients with a breast malignancy smaller than 4 cm in diameter were treated by lumpectomy and radiotherapy, anti-oestrogen therapy or chemotherapy alone or in combination. Psychological morbidity among patients with malignant disease was significantly greater than that seen in the group with benign disease. Among cancer patients, a significant decrease in anxiety and depression occurred during the year following surgery. The study failed to demonstrate any psychological advantage associated with breast conservation.
在这项前瞻性研究中，对与乳腺癌治疗相关的心理疾病进行了评估。研究人群包括所有转诊至一个中心、近期诊断为乳腺肿块且即将接受手术的患者。术前以及术后6个月和12个月时，通过改良的鹿特丹症状清单对心理疾病进行评估。320名患者完成了所有三份问卷：93名接受乳房切除术的女性、73名接受乳腺癌保乳治疗的女性以及156名接受乳腺良性疾病活检的女性。直径小于4厘米的乳腺恶性肿瘤患者接受肿块切除术和放疗、抗雌激素治疗或单独或联合化疗。恶性疾病患者的心理疾病明显多于良性疾病组。在癌症患者中，术后一年焦虑和抑郁显著减轻。该研究未能证明保乳有任何心理优势。
