抗菌药物对肝脏和小肠中胆固醇合成及含量的影响。
Effect of antimicrobials on cholesterol synthesis and content in liver and small intestines.
作者信息
Pugalendhi K V, Sudhakaran P R, Ramakrishnan S
机构信息
Department of Biochemistry, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalainagar, India.
出版信息
Indian J Exp Biol. 1992 Feb;30(2):152-4.
The antimicrobials tetracycline, ampicillin and bactrim (cotrimoxazole) decreased HMG CoA reductase activity in liver and small intestines of albino rats. Diminished incorporation of 1, 2, 14C acetate into cholesterol of small intestines in bactrim group was noted. There was a significant fall in cholesterol content of liver, duodenum, jejunum and ileum of the bactrim group and jejunum only in tetracycline group.
抗菌药物四环素、氨苄青霉素和复方新诺明（甲氧苄啶磺胺甲恶唑）降低了白化大鼠肝脏和小肠中HMG CoA还原酶的活性。观察到复方新诺明组小肠中1,2,14C乙酸掺入胆固醇的量减少。复方新诺明组肝脏、十二指肠、空肠和回肠的胆固醇含量显著下降，四环素组仅空肠的胆固醇含量显著下降。
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