Kannagi Mari, Ohashi Takashi, Harashima Nanae, Hanabuchi Shino, Hasegawa Atsuhiko
Department of Immunotherapeutics, Medical Research Division, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
Trends Microbiol. 2004 Jul;12(7):346-52. doi: 10.1016/j.tim.2004.05.005.
A small percentage of human T-cell leukemia virus type-I (HTLV-I)-infected individuals develop adult T-cell leukemia (ATL). In animal experiments, inoculation of HTLV-I via the oral route, which is the main route of mother-to-child viral transmission in humans as a result of breastfeeding, induced host HTLV-I-specific T-cell unresponsiveness and resulted in increased viral load. This strongly suggested that the known epidemiological risk factors for ATL (i.e. vertical HTLV-I infection and elevated viral load) are linked by an insufficient HTLV-I-specific T-cell response. Recent findings on the anti-tumor effects of Tax-targeted vaccination in rats and the reactivation of Tax-specific T cells in ATL patients as a result of hematopoietic stem cell transplantation imply promising immunological approaches for the prophylaxis and therapy of ATL.
一小部分感染I型人类T细胞白血病病毒（HTLV-I）的个体发展为成人T细胞白血病（ATL）。在动物实验中，通过口服途径接种HTLV-I（这是人类中因母乳喂养导致母婴病毒传播的主要途径）会诱导宿主HTLV-I特异性T细胞无反应性，并导致病毒载量增加。这有力地表明，ATL已知的流行病学危险因素（即HTLV-I垂直感染和病毒载量升高）是由HTLV-I特异性T细胞反应不足联系起来的。最近关于针对Tax的疫苗接种在大鼠中的抗肿瘤作用以及造血干细胞移植导致ATL患者中Tax特异性T细胞重新激活的研究结果，暗示了预防和治疗ATL的有前景的免疫方法。
Zotero 插件