Lee Ming, Pao David, Hsu Tom, Sonderskov Anne
Pharmacy Services, Rouge Valley Health System, Toronto, Canada.
Can J Clin Pharmacol. 2004 Spring;11(1):e17-27. Epub 2004 Apr 1.
This study was conducted at Centenary Health Centre of the Rouge Valley Health System, a community based hospital in Toronto. In January 1997, a new treatment was introduced for the management of patients with uncomplicated deep vein thrombosis (DVT). Eligible patients presenting at the ER were placed on LMWH (tinzaparin) and followed at home. Previously the patients had been hospitalized and treated with intravenous heparin until they reached a therapeutic international normalized ratio (INR). The intent of this study was to evaluate the patient outcomes and cost-savings of the new approach.
Data from all patients eligible for home care, treated in 1996 were assembled and compared with those from all eligible patients treated from April 1, 1997 to March 31, 1998. The data was collected by chart review and consisted of patient outcomes and costs during the period of heparin treatment. Costs for hospitalized patients were based on a per diem. For home care patients, the costs were itemized according to service and medication usage. All costs were calculated in 1999 Canadian dollars.
In each one year period, 39 cases were treated. There was no serious adversity and the outcomes were compatible with what has been reported in the literature. The mean cost per patient for the 1996 hospitalized cohort was $3,266 compared to $584 for the subsequent home care cohort. The difference was statistically significant (p<0.00001).
Home care with tinzaparin compared to hospital care with IV heparin resulted in a large mean saving per patient with no difference in outcome.
本研究在多伦多一家社区医院鲁治谷健康系统的百年健康中心进行。1997年1月,引入了一种新的治疗方法来管理无并发症的深静脉血栓形成(DVT)患者。在急诊室就诊的符合条件的患者接受低分子肝素(替扎肝素)治疗并在家中接受随访。此前,患者需住院并接受静脉肝素治疗,直至达到治疗性国际标准化比值(INR)。本研究的目的是评估这种新方法的患者预后和成本节约情况。
收集1996年所有符合家庭护理条件的患者的数据,并与1997年4月1日至1998年3月31日期间所有符合条件的患者的数据进行比较。数据通过病历审查收集,包括肝素治疗期间的患者预后和成本。住院患者的费用按每日计算。对于家庭护理患者,费用根据服务和药物使用情况逐项列出。所有费用均以1999年加拿大元计算。
在每个一年期内,治疗了39例患者。没有严重不良事件,预后与文献报道相符。1996年住院队列中每位患者的平均费用为3266加元,而随后家庭护理队列的平均费用为584加元。差异具有统计学意义(p<0.00001)。
与静脉注射肝素的医院护理相比,替扎肝素家庭护理使每位患者平均节省大量费用,且预后无差异。