Volicer Ladislav, Lane Patricia, Panke JoAnn, Lyman Paul
Geriatrics Research Education Clinical Center, E.N. Rogers Memorial Veterans Hospital, Bedford, and Boston University School of Medicine, Department of Pharmacology, MA, USA.
J Am Med Dir Assoc. 2004 Jul-Aug;5(4):239-41. doi: 10.1097/01.JAM.0000129819.82144.A0.
The objective of this report is to describe a cost-effective strategy for management of constipation in nursing home residents with dementia.
We conducted a prospective observational quality improvement study of 41 residents with chronic constipation and receiving an osmotic laxative. Sorbitol was substituted for lactulose.
The study was conducted at a dementia special care unit at a Veterans Administration hospital.
We measured the number and amount of laxative use over a period of 4 weeks that were required to maintain regular bowel function.
There was no difference in efficacy of lactulose and sorbitol. Use of additional laxatives was infrequent: Milk of Magnesia on approximately 10% of days/patient, bisacodyl suppository on 2% to 4% of days/patient, and Fleet enema only on 3 occasions. The cost of constipation management using routine administration of sorbitol and as-needed use of other laxatives was 27% to 55% lower than the cost of other constipation management strategies reported in the literature.
Substitution of sorbitol for lactulose does not change efficacy of the treatment and decreases cost. Regular use of an osmotic laxative avoids the costs and discomforts of rectal laxatives.
本报告旨在描述一种针对患有痴呆症的养老院居民便秘管理的经济有效策略。
我们对41名患有慢性便秘且正在接受渗透性泻药治疗的居民进行了一项前瞻性观察性质量改进研究。用山梨醇替代了乳果糖。
该研究在一家退伍军人管理局医院的痴呆症特殊护理病房进行。
我们测量了在4周时间内维持正常排便功能所需的泻药使用次数和用量。
乳果糖和山梨醇的疗效没有差异。很少需要额外使用泻药:约10%的天数/患者使用氢氧化镁乳剂,2%至4%的天数/患者使用比沙可啶栓剂,仅3次使用灌肠剂。使用常规剂量山梨醇并按需使用其他泻药进行便秘管理的成本比文献中报道的其他便秘管理策略低27%至55%。
用山梨醇替代乳果糖不会改变治疗效果,且能降低成本。定期使用渗透性泻药可避免直肠泻药的成本和不适。