Apoola A, Radcliffe K
Whittall Street Clinic, Whittall Street, Birmingham B4 6DH, UK.
Int J STD AIDS. 2004 Jul;15(7):429-33. doi: 10.1258/0956462041211153.
A review of the randomized, controlled trials in the literature on the treatment of genital herpes infection with aciclovir, famciclovir and valaciclovir. Common clinical questions encountered by physicians, such as the effect of antivirals on symptoms, healing, aborting attacks and subsequent recurrences, are addressed. There is very little comparative data between the three licensed drugs but the little data that there is shows no difference in efficacy, tolerability and toxicity between aciclovir, valaciclovir or famciclovir when taken orally. Choice of therapy would then depend on convenience of dosing and cost.
对文献中关于用阿昔洛韦、泛昔洛韦和伐昔洛韦治疗生殖器疱疹感染的随机对照试验的综述。文中探讨了医生遇到的常见临床问题，如抗病毒药物对症状、愈合、中止发作及后续复发的影响。这三种已获许可的药物之间的比较数据非常少，但现有的少量数据表明，口服阿昔洛韦、伐昔洛韦或泛昔洛韦时，它们在疗效、耐受性和毒性方面并无差异。治疗方案的选择将取决于给药便利性和成本。
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