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Ligation of CD8 leads to apoptosis of thymocytes that have not undergone positive selection.
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2
TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis.
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3
Signal transduction via CD4, CD8, and CD28 in mature and immature thymocytes. Implications for thymic selection.
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CD3-induced apoptosis of CD4+CD8+ thymocytes in the absence of clonotypic T cell antigen receptor.
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Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes.
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Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes.
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7
CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation.
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8
Antigen-induced coreceptor down-regulation on thymocytes is not a result of apoptosis.
J Immunol. 1999 Feb 1;162(3):1237-45.
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Cross-talk between the T cell antigen receptor and the glucocorticoid receptor regulates thymocyte development.
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Survival and Developmental Progression of Unselected Thymocytes in the Absence of the T-Cell Adaptor Gads.
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Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential.
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4
Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.
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Interaction between the mouse homologue of CD99 and its ligand PILR as a mechanism of T cell receptor-independent thymocyte apoptosis.
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MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
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A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction.
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Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis.
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THE INFLUENCE OF THE SUPRARENAL GLAND ON THE THYMUS : III. STIMULATION OF THE GROWTH OF THE THYMUS GLAND FOLLOWING DOUBLE SUPRARENALECTOMY IN YOUNG RATS.
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The Ras/MAPK cascade and the control of positive selection.
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Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo.
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T-cell development and the CD4-CD8 lineage decision.
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CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation.
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Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.
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The CD8alphabeta co-receptor on double-positive thymocytes binds with differing affinities to the products of distinct class I MHC loci.
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Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD.
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Protein kinase C theta and epsilon promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD.
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Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells.
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