肌球蛋白III揭示了抑制蛋白易位的机制。

Myosin III illuminates the mechanism of arrestin translocation.

作者信息

Strissel Katherine J, Arshavsky Vadim Y

机构信息

Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.

出版信息

Neuron. 2004 Jul 8;43(1):2-4. doi: 10.1016/j.neuron.2004.06.026.

DOI:10.1016/j.neuron.2004.06.026

PMID:15233912

Abstract

Recent studies have revealed that light adaptation of both vertebrate and invertebrate photoreceptors is accompanied by massive translocations of major signaling proteins in and out of the cellular compartments where visual signal transduction takes place. In this issue of Neuron, Lee and Montell report a breakthrough in understanding the mechanism of arrestin translocation in Drosophila. They show that arrestin is carried into the light-sensitive microvilli by phosphoinositide-enriched vesicles driven by a myosin motor.

摘要

最近的研究表明，脊椎动物和无脊椎动物的光感受器在光适应过程中，主要信号蛋白会大量进出视觉信号转导发生的细胞区室。在本期《神经元》杂志中，李和蒙特尔报道了在理解果蝇中抑制蛋白转运机制方面的一项突破。他们发现，抑制蛋白由富含磷酸肌醇的囊泡携带进入光敏感微绒毛，该囊泡由肌球蛋白驱动。