Patel Manesh R, Meine Trip J, Radeva Jasmina, Curtis Lesley, Rao Sunil V, Schulman Kevin A, Jollis James G
Duke Clinical Research Institute, Durham, North Carolina 27715, USA.
J Am Coll Cardiol. 2004 Jul 7;44(1):192-8. doi: 10.1016/j.jacc.2004.03.070.
The purpose of this study was to determine whether state-mandated continuing medical education (CME) requirements affect the use of evidence-based therapies and outcomes in patients with acute myocardial infarction (AMI).
The Institute of Medicine recommends that educational programs demonstrate their effect through process and outcome measures.
We analyzed 134,609 patients according to whether or not CME was mandated in the state of physician practice. A hierarchical multivariable model was developed that controlled for state, hospital, physician, and patient level characteristics to determine the association between state CME requirements and the use of evidence-based therapies. Primary outcome measures were admission aspirin use and reperfusion therapy, and discharge aspirin and beta-blocker prescription. Thirty-day and one-year mortality were secondary outcome measures.
States with and without CME requirements had similar rates of aspirin use at admission and discharge (79.9% vs. 79.4% and 72.5% vs. 72.5%, respectively) and beta-blocker prescription at discharge (53.6% vs. 55.3%). The rate of reperfusion therapy at admission was significantly higher in states requiring CME (53.1%) compared with states without CME (47.9%) (p < 0.0001). After adjustment, patients admitted in CME-requiring states were significantly more likely to receive reperfusion therapy, mainly owing to "patented" thrombolytic therapy (odds ratio 1.15; p = 0.016). There was no association between CME requirements and one-year mortality.
State-mandated CME had little association with AMI care or outcome, other than an increased use of patented thrombolytic therapy. Further research is needed to maximize the measurable effect of CME on the use of proven therapies irrespective of whether patented or generic medications are involved.
本研究旨在确定州政府规定的继续医学教育(CME)要求是否会影响急性心肌梗死(AMI)患者基于证据的治疗方法的使用和治疗结果。
医学研究所建议教育项目应通过过程和结果指标来证明其效果。
我们根据医生执业所在州是否规定CME,对134,609例患者进行了分析。建立了一个分层多变量模型,该模型控制了州、医院、医生和患者层面的特征,以确定州CME要求与基于证据的治疗方法使用之间的关联。主要结局指标为入院时阿司匹林的使用情况和再灌注治疗,以及出院时阿司匹林和β受体阻滞剂的处方情况。30天和1年死亡率为次要结局指标。
有CME要求的州和没有CME要求的州在入院和出院时阿司匹林的使用率相似(分别为79.9%对79.4%和72.5%对72.5%),出院时β受体阻滞剂的处方率也相似(53.6%对55.3%)。与没有CME要求的州(47.9%)相比,要求CME的州入院时再灌注治疗的比例显著更高(53.1%)(p < 0.0001)。调整后,在要求CME的州入院的患者接受再灌注治疗的可能性显著更高,主要是由于“专利”溶栓治疗(优势比1.15;p = 0.016)。CME要求与1年死亡率之间没有关联。
除了专利溶栓治疗的使用增加外,州政府规定的CME与AMI护理或结局几乎没有关联。需要进一步研究,以最大限度地提高CME对已证实治疗方法使用的可衡量效果,无论涉及的是专利药物还是通用药物。