血管内皮生长因子受体-3介导角膜同种免疫反应的诱导。

Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity.

作者信息

Chen Lu, Hamrah Pedram, Cursiefen Claus, Zhang Qiang, Pytowski Bronislaw, Streilein J Wayne, Dana M Reza

机构信息

Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA.

出版信息

Nat Med. 2004 Aug;10(8):813-5. doi: 10.1038/nm1078. Epub 2004 Jul 4.

DOI:10.1038/nm1078

PMID:15235599

Abstract

There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.

摘要

目前尚无研究将淋巴管生成的分子调控与适应性免疫的诱导联系起来。在此，我们表明，血管内皮生长因子受体-3（VEGFR-3）信号通路的阻断显著抑制角膜抗原呈递（树突状）细胞向引流淋巴结的迁移、迟发型超敏反应的诱导以及角膜移植排斥反应。因此，调节VEGFR-3的功能可能是在外周调节适应性免疫的一种机制。