Qazi Shabir A, Mohammed Abdulmajeed A, Saber Elsanousi I, Mirza Shaukat M
Department of General Surgery, Riyadh Medical Complex, Kingdom of Saudi Arabia.
Saudi Med J. 2004 Jul;25(7):890-4.
To evaluate our experience of management of necrotizing fasciitis (NF) particularly the role of early and aggressive surgical intervention.
This is a retrospective review of the cases affected by this disease and managed at Riyadh Medical Complex, Riyadh, Kingdom of Saudi Arabia, during 5 calendar years from 1996 through to 2000 (1416-1420 A.H). The preoperative and operative data was collected, and postoperative morbidity and mortality were analyzed.
A total of 25 cases of NF were treated during the 5-year period, 18 were males and 7 female. The majority of patients had perianal suppuration as the primary lesion, followed by groin area in drug addicts and only 2 cases were primarily in the upper limbs. Diabetes and drug addiction were the main predisposing factors. All but 3 infections were polymicrobial, with streptococci and acinobacter being the most frequent organisms. The mainstay of treatment depends on a high index of suspicion, aggressive early and repeated debridements and adequate antibiotic coverage. The overall mortality was 24% but the drastic reduction in mortality was observed with early surgical intervention.
The results highlight the role of early diagnosis; prompt and aggressive surgical debridements are critical for improved survival.
评估我们对坏死性筋膜炎(NF)的治疗经验,尤其是早期积极手术干预的作用。
这是一项对1996年至2000年(回历1416 - 1420年)在沙特阿拉伯王国利雅得利雅得医疗中心诊治的该病患者病例的回顾性研究。收集术前和手术数据,并分析术后发病率和死亡率。
在这5年期间共治疗了25例NF患者,其中男性18例,女性7例。大多数患者以肛周化脓为主要病变,其次是吸毒者的腹股沟区,仅有2例主要累及上肢。糖尿病和吸毒是主要的诱发因素。除3例感染外,所有感染均为多微生物感染,链球菌和不动杆菌是最常见的病原体。治疗的关键在于高度的怀疑指数、早期积极且反复的清创以及充分的抗生素覆盖。总体死亡率为24%,但早期手术干预使死亡率大幅降低。
结果突出了早期诊断的作用;及时且积极的手术清创对于提高生存率至关重要。