在人类B细胞发育的NOD/SCID模型中观察到免疫球蛋白重链受体编辑。

Immunoglobulin heavy-chain receptor editing is observed in the NOD/SCID model of human B-cell development.

作者信息

Kolar G R, Capra J D

机构信息

Program in Molecular Immunogenetics, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73003, USA.

出版信息

Scand J Immunol. 2004 Jul-Aug;60(1-2):108-11. doi: 10.1111/j.0300-9475.2004.01467.x.

DOI:10.1111/j.0300-9475.2004.01467.x

PMID:15238079

Abstract

Receptor editing and receptor revision are the two mechanisms of antibody diversity that result in either complete V-gene replacement or the formation of hybrid V genes. We do not yet understand how this process unfolds, because they are rare and difficult to study in vivo. In this study, we describe a family of VH4-34:VH4-61 hybrids isolated from a human B-cell chimeric non-obese diabetic/severe combined immunodeficient mouse. The observation of hybrid immunoglobulin sequences in human B cells that developed in this model system makes it useful for the study of this mechanism of diversification and tolerance.

摘要

受体编辑和受体修正为抗体多样性的两种机制，它们分别导致V基因的完全替换或杂交V基因的形成。我们尚不了解这一过程是如何展开的，因为它们很罕见且难以在体内进行研究。在本研究中，我们描述了从一只人B细胞嵌合非肥胖糖尿病/重症联合免疫缺陷小鼠中分离出的VH4-34:VH4-61杂交体家族。在该模型系统中发育的人B细胞中观察到杂交免疫球蛋白序列，这使其对于研究这种多样化和耐受性机制很有用。