新型胆碱酯酶抑制剂的半数抑制浓度。

Half-inhibition concentrations of new cholinesterase inhibitors.

作者信息

Zdrazilová Pavla, Stepánková Sárka, Komers Karel, Ventura Karel, Cegan Alexander

机构信息

Faculty of Chemical Technology, University of Pardubice, Department of Physical Chemistry, Pardubice, Czech Republic.

出版信息

Z Naturforsch C J Biosci. 2004 Mar-Apr;59(3-4):293-6. doi: 10.1515/znc-2004-3-430.

DOI:10.1515/znc-2004-3-430

PMID:15241943

Abstract

The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer's disease treatment--rivastigmine and galanthamine.

摘要

测试了所选氨基甲酸酯和肼鎓衍生物（氨基脲）抑制丁酰胆碱酯酶或乙酰胆碱酯酶水解乙酰硫代胆碱的能力。将测试物质的测定pI50值（=抑制酶活性50%的摩尔浓度的负对数）与用于治疗阿尔茨海默病的商业药物利伐斯的明和加兰他敏的pI50值进行比较。