中脑代谢减退作为进行性核上性麻痹的早期诊断标志。
Midbrain hypometabolism as early diagnostic sign for progressive supranuclear palsy.
作者信息
Mishina M, Ishii K, Mitani K, Ohyama M, Yamazaki M, Ishiwata K, Senda M, Kobayashi S, Kitamura S, Katayama Y
机构信息
The Department of Neurology, Neurological Institute, Nippon Medical School Chiba-Hokusoh Hospital, Inba-gun, Chiba, Japan.
出版信息
Acta Neurol Scand. 2004 Aug;110(2):128-35. doi: 10.1111/j.1600-0404.2004.00293.x.
OBJECTIVE
Progressive supranuclear palsy (PSP) is often misdiagnosed in early phase. The purpose of this study is to investigate the feature of [(18)F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography images for the early diagnosis of PSP.
METHODS
We studied 15 patients with PSP and 16 normal subjects. Using SPM99 and analysis of covariance to eliminate the effect of aging, the differences between PSP and normals were displayed as a statistical map. In the PSP, we also investigated the correlation with duration and with the subscores of Unified Parkinson's Disease Rating Scale.
RESULTS
The glucose metabolism of midbrain was significantly lower in PSP than in normals. However, correlation was not found between the metabolism of midbrain and clinical deterioration.
CONCLUSIONS
The statistical map clearly demonstrated the hypometabolism of midbrain in PSP, which is independent of the clinical deterioration. The hypometabolism of midbrain is one of the most promising sign for early diagnosis of PSP.
目的
进行性核上性麻痹（PSP）在早期常被误诊。本研究旨在探讨[（18）F]氟代脱氧葡萄糖（FDG）正电子发射断层扫描图像在PSP早期诊断中的特征。
方法
我们研究了15例PSP患者和16名正常受试者。使用SPM99和协方差分析来消除衰老的影响，PSP患者与正常受试者之间的差异以统计图的形式呈现。在PSP患者中，我们还研究了其与病程以及统一帕金森病评定量表各分项评分的相关性。
结果
PSP患者中脑的葡萄糖代谢显著低于正常受试者。然而，未发现中脑代谢与临床病情恶化之间存在相关性。
结论
统计图清楚地显示了PSP患者中脑代谢减低，且这一现象与临床病情恶化无关。中脑代谢减低是PSP早期诊断中最有前景的征象之一。
Zotero 插件