Carrascosa Antonio, Ruiz-Cuevas Pilar, Potau Neus, Almar Jordi, Salcedo Salvador, Clemente María, Yeste Diego
Pediatric Endocrine Service, Children's Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.
Thyroid. 2004 Jun;14(6):435-42. doi: 10.1089/105072504323150741.
Thyroid function was evaluated in 75 healthy preterm infants, 30-35 weeks of gestational age. Serum thyrotropin (TSH), thyroxine (T(4)), triiodothyronine (T(3)), free T(4) (immunochemoluminescence) and reverse triiodothyronine (rT(3)) (radioimmunoassay) were measured in the mother and in the cord at delivery and in the preterm infants at 1 hour, 24 hours, 1 week, 3 weeks, 2 months, 4 months, 6 months, and 12 months of postnatal age. These values were compared to those of healthy full-term infants of the same postnatal age (22 at 24 hours from our hospital and from previously reported data at others times). Mean 24-hour TSH values were significantly lower (p < 0.001) in preterm than in full-term infant populations (12.38 +/- 6.13 microIU/mL versus 22.02 +/- 13.28 microIU/mL); however, all TSH values of preterm infants were in the range of the full-term values. Mean 24-hour free T(4) values were similar in preterm and full-term infants (1.88 +/- 0.46 ng/dL versus 2.01 +/- 0.54 ng/dL) and all preterm infants had free T(4) values within the range of those of full-term infants at 24 hours. Mean T(4) and T(3) values were significantly lower in preterm than in full-term neonates at 1 hour and 24 hours of age. Mean 24-hour rT(3) values were significantly higher in preterm than in full-term newborns. From 1 week onwards, all thyroid function values were in the same range in both populations. In conclusion, individual thyroid function was similar in healthy preterms and full-terms from the first 24 hours of life. Normative data in preterm infants during the first year of life applying the latest luminescence techniques currently used worldwide are reported.
对75名胎龄为30 - 35周的健康早产儿进行了甲状腺功能评估。在母亲分娩时的脐带血以及早产儿出生后1小时、24小时、1周、3周、2个月、4个月、6个月和12个月时，检测血清促甲状腺激素（TSH）、甲状腺素（T4）、三碘甲状腺原氨酸（T3）、游离T4（免疫化学发光法）和反三碘甲状腺原氨酸（rT3）（放射免疫分析法）。将这些值与相同出生后年龄的健康足月儿的值进行比较（我院24小时时的22例以及其他时间先前报道的数据）。早产儿24小时平均TSH值显著低于足月儿群体（p < 0.001）（12.38±6.13微国际单位/毫升对22.02±13.28微国际单位/毫升）；然而，早产儿的所有TSH值都在足月儿值的范围内。早产儿和足月儿24小时平均游离T4值相似（1.88±0.46纳克/分升对2.01±0.54纳克/分升），并且所有早产儿在24小时时的游离T4值都在足月儿的范围内。早产儿在1小时和24小时时的平均T4和T3值显著低于足月儿新生儿。早产儿24小时平均rT3值显著高于足月儿新生儿。从1周起，两个群体的所有甲状腺功能值都在相同范围内。总之，健康早产儿和足月儿在出生后最初24小时内的个体甲状腺功能相似。报告了应用目前全球使用的最新发光技术得出的早产儿出生后第一年的规范数据。
