使守护者发生Neddylation修饰；Mdm2催化Nedd8与p53的缀合反应。
Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.
作者信息
Harper J Wade
机构信息
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
出版信息
Cell. 2004 Jul 9;118(1):2-4. doi: 10.1016/j.cell.2004.06.015.
PMID:15242638
Abstract
The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.
摘要
肿瘤抑制因子和转录调节因子p53可能是细胞核中受调控最多的蛋白质之一，它会受到多种蛋白激酶、乙酰化酶、泛素连接酶、水解酶以及SUMO偶联酶的作用。现在，新的研究表明，另一种修饰——NEDDylation（类泛素化修饰）——在p53转录活性的负调控中发挥作用。
Zotero 插件