患有和未患有子宫内膜异位症的患者之间，腹腔液中CA - 125、CA 19 - 9和CA 15 - 3的高浓度情况。

High concentrations of the CA-125, CA 19-9 and CA 15-3 in the peritoneal fluid between patients with and without endometriosis.

作者信息

Matalliotakis Ioannis M, Goumenou Anastasia G, Mulayim Naciye, Karkavitsas Nikolaos, Koumantakis Eugenios E

机构信息

Department of Obstetrics and Gynecology, University of Crete, P.O. Box 1393, 714-9 Heraklion, Crete, Greece.

出版信息

Arch Gynecol Obstet. 2005 Jan;271(1):40-5. doi: 10.1007/s00404-004-0645-7. Epub 2004 Jul 9.

DOI:10.1007/s00404-004-0645-7

PMID:15243756

Abstract

OBJECTIVE

In the present study we compared the levels of CA-125, CA 19-9, and CA 15-3 in the peritoneal fluid (PF) of patients with and without endometriosis, then assessed the possibility of a correlation among these tumor markers.

STUDY DESIGN

Our study was a controlled clinical study of patients undergoing laparoscopy for infertility or other benign gynecology conditions. Peritoneal fluid samples were collected from 65 women with endometriosis and 43 women without pelvic disease. Levels of CA-125, CA 19-9 and CA 15-3 in the peritoneal fluid were determined by immunoradiometric assay.

RESULTS

The concentration of CA-125 in PF from patients with endometriosis was significantly higher than that in the control group (p<0.001); for CA 19-9 and CA 15-3, PF concentrations were not statistically different between these two groups. Women with endometriosis had significantly higher levels of CA-125 in proliferative and secretory phases than the control group (p<0.001 and p<0.002 respectively); furthermore, in patients with endometriosis the CA 19-9 levels were significantly lower in secretory phase than the proliferative (p<0.004). The levels of CA-125 were significantly lower in women with tubal ligation, in comparison with infertility or pelvic pain in the control group (p<0.001). No significant difference was seen in women with infertility or pelvic pain in endometriosis group and the levels of CA-125, CA 19-9, and CA 15-3. We did not find any correlation between the stages of endometriosis and the concentration of CA-125, CA 19-9 and CA 15-3. A significant correlation between the CA 19-9 levels and CA 15-3 in patients with endometriosis was found (r=0.72, p=0.001).

CONCLUSIONS

We found high concentrations of CA-125, CA 19-9, and CA 15-3 in the peritoneal fluid of women with and without endometriosis in the Yale series. However, the levels only of CA-125 were higher in women with endometriosis, but without diagnostic value. The role of simultaneously high concentrations of CA 19-9 and CA 15-3 in women with endometriosis needs to be explored further.

摘要

目的

在本研究中，我们比较了患有和未患有子宫内膜异位症患者的腹腔液（PF）中CA - 125、CA 19 - 9和CA 15 - 3的水平，然后评估了这些肿瘤标志物之间存在相关性的可能性。

研究设计

我们的研究是一项针对因不孕症或其他良性妇科疾病接受腹腔镜检查患者的对照临床研究。从65名患有子宫内膜异位症的女性和43名无盆腔疾病的女性中采集腹腔液样本。通过免疫放射分析测定腹腔液中CA - 125、CA 19 - 9和CA 15 - 3的水平。

结果

子宫内膜异位症患者腹腔液中CA - 125的浓度显著高于对照组（p<0.001）；对于CA 19 - 9和CA 15 - 3，两组之间腹腔液浓度无统计学差异。子宫内膜异位症女性在增殖期和分泌期的CA - 125水平显著高于对照组（分别为p<0.001和p<0.002）；此外，子宫内膜异位症患者分泌期的CA 19 - 9水平显著低于增殖期（p<0.004）。与对照组中因不孕症或盆腔疼痛的女性相比，输卵管结扎女性的CA - 125水平显著较低（p<0.001）。子宫内膜异位症组中因不孕症或盆腔疼痛的女性与CA - 125、CA 19 - 9和CA 15 - 3水平之间未发现显著差异。我们未发现子宫内膜异位症分期与CA - 125、CA 19 - 9和CA 15 - 3浓度之间存在任何相关性。发现子宫内膜异位症患者的CA 19 - 9水平与CA 15 - 3之间存在显著相关性（r = 0.72，p = 0.001）。