Joseph Sarah, Jones Frances M, Laidlaw Maureen E, Mohamed Gamal, Mawa Patrice A, Namujju Proscovia B, Kizza Moses, Watera Christine, Whitworth James A G, Dunne David W, Elliott Alison M
Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
J Infect Dis. 2004 Aug 1;190(3):613-8. doi: 10.1086/422396. Epub 2004 Jul 1.
We show that Ugandan adults coinfected with Schistosoma mansoni and human immunodeficiency virus type 1 (HIV-1) are able to mount S. mansoni-specific immune responses but that few such responses increase after treatment with praziquantel (PZQ). Levels of soluble worm antigen (SWA)-specific immunoglobulin (Ig) G1, IgG2, IgG3, IgG4, interleukin (IL)-4, and IL-5 increased significantly in HIV-negative participants after treatment with PZQ, whereas most soluble egg antigen-specific antibody responses and levels of interferon- gamma were unaltered. Only levels of SWA-specific IL-5 increased in HIV-1-coinfected participants after treatment. These deficiencies in immune responses may account for the previously reported increased susceptibility to infection and reinfection with S. mansoni in individuals coinfected with HIV-1.
我们发现，乌干达同时感染曼氏血吸虫和1型人类免疫缺陷病毒（HIV-1）的成年人能够产生针对曼氏血吸虫的特异性免疫反应，但在用吡喹酮（PZQ）治疗后，此类反应很少增加。在HIV阴性参与者中，用PZQ治疗后，可溶性虫抗原（SWA）特异性免疫球蛋白（Ig）G1、IgG2、IgG3、IgG4、白细胞介素（IL）-4和IL-5水平显著升高，而大多数可溶性虫卵抗原特异性抗体反应和干扰素-γ水平未改变。在接受治疗后的HIV-1合并感染参与者中，只有SWA特异性IL-5水平升高。这些免疫反应缺陷可能解释了先前报道的HIV-1合并感染个体对曼氏血吸虫感染和再感染易感性增加的原因。
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