神经性厌食症和神经性贪食症患者的精神病理特征与5-HT2A受体启动子多态性（-1438 G/A）

Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa.

作者信息

Ricca Valdo, Nacmias Benedetta, Boldrini Maura, Cellini Elena, di Bernardo Milena, Ravaldi Claudia, Tedde Andrea, Bagnoli Silvia, Placidi Gian Franco, Rotella Carlo Maria, Sorbi Sandro

机构信息

Department of Neurological and Psychiatric Sciences, Psychiatry Unit, University of Florence, Viale Morgagni, 85, 50134, Italy.

出版信息

Neurosci Lett. 2004 Jul 22;365(2):92-6. doi: 10.1016/j.neulet.2004.04.057.

DOI:10.1016/j.neulet.2004.04.057

PMID:15245785

Abstract

Various studies have evaluated the possible role of the -1438G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P = 0.003 and P = 0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P = 0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studies.

摘要

多项研究评估了5-羟色胺2A受体基因内-1438G/A多态性在饮食失调（EDs）易感性中的可能作用。通过饮食失调检查（EDE）对148名饮食失调患者（EDp）和89名对照受试者进行了访谈，并分析了-1438G/A多态性的分布。患有神经性厌食症和神经性贪食症的AA基因型患者表现出更高的体重和体型关注度（分别为P = 0.003和P = 0.010）得分以及更高的饮食失调精神病理学总体严重程度（EDE总分）（P = 0.012）。获得的初步数据表明在饮食失调基因研究中应使用维度精神病理学测量方法。