Fattorini Lanfranco, Gennaro Renato, Zanetti Margherita, Tan Dejiang, Brunori Lara, Giannoni Federico, Pardini Manuela, Orefici Graziella
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
Peptides. 2004 Jul;25(7):1075-7. doi: 10.1016/j.peptides.2004.04.003.
The antimicrobial peptide protegrin-1 (PG-1) inhibited the growth in vitro of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis; a lower activity was shown by human beta-defensin-1 (HBD-1) against both strains. The combination of PG-1 or HBD-1 with isoniazid significantly reduced M. tuberculosis growth in comparison with the peptides or isoniazid alone.
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