Nguewa Paul A, Fuertes Miguel A, Valladares Basilio, Alonso Carlos, Pérez José M
Departamento de Parasitología, Facultad de Farmacia, Universidad de la Laguna, 38071 La Laguna, Tenerife, Spain.
Trends Parasitol. 2004 Aug;20(8):375-80. doi: 10.1016/j.pt.2004.05.006.
Programmed cell death (PCD) is a biochemical process that plays an essential role in the development of multicellular organisms. However, accumulating evidence indicates that PCD is also present in single-celled eukaryotes. Thus, trypanosomatids might be endowed with a PCD mechanism that is derived from ancestral death machinery. PCD in trypanosomatids could be a process without a defined function, inherited through eukaryotic cell evolution, which might be triggered in response to diverse stimuli and stress conditions. However, recent observations suggest that PCD might be used by trypanosomatids to maximize their biological fitness. Therefore, PCD could represent a potential pharmacological target for protozoan control.
程序性细胞死亡（PCD）是一种在多细胞生物体发育过程中发挥重要作用的生化过程。然而，越来越多的证据表明，PCD也存在于单细胞真核生物中。因此，锥虫可能具有源自祖先死亡机制的PCD机制。锥虫中的PCD可能是一个没有明确功能的过程，通过真核细胞进化遗传而来，可能会在多种刺激和应激条件下被触发。然而，最近的观察结果表明，锥虫可能利用PCD来最大化其生物学适应性。因此，PCD可能是控制原生动物的一个潜在药理学靶点。
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