荷瘤小鼠体内¹⁰B生物分布的中子俘获放射自显影研究。

Neutron capture autoradiographic study of the biodistribution of 10B in tumor-bearing mice.

作者信息

Ogura K, Yanagie H, Eriguchi M, Lehmann E H, Kühne G, Bayon G, Kobayashi H

机构信息

High Technology Research Center, College of Industrial Technology, Nihon University, 1-2-1, Izumi-cho, Narashino, Chiba 275-0005, Japan.

出版信息

Appl Radiat Isot. 2004 Oct;61(4):585-90. doi: 10.1016/j.apradiso.2004.03.084.

DOI:10.1016/j.apradiso.2004.03.084

PMID:15246403

Abstract

For the study on boron neutron capture therapy, the whole-body sections of tumor-bearing mice infused with 10B attached to CR-39 plastic track detectors were exposed to thermal and cold neutron beams. Neutron capture autoradiographic images obtained by the cold neutron irradiation were extremely superior in quality to those of the thermal neutron beams. From the autoradiographic images, the 10B reaction dose of the neutron-induced particles was estimated using the differential LET distribution.

摘要

在硼中子俘获疗法的研究中，将附着有10B的CR-39塑料径迹探测器注入荷瘤小鼠体内，然后对其全身切片进行热中子束和冷中子束照射。冷中子照射获得的中子俘获放射自显影图像在质量上比热中子束照射的图像优越得多。根据放射自显影图像，利用微分传能线密度分布估算中子诱发粒子的10B反应剂量。