连接肿瘤抑制、DNA损伤与后期促进复合物

Linking tumor suppression, DNA damage and the anaphase-promoting complex.

作者信息

Jackson Peter K

机构信息

Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, CA 94305, USA.

出版信息

Trends Cell Biol. 2004 Jul;14(7):331-4. doi: 10.1016/j.tcb.2004.05.005.

DOI:10.1016/j.tcb.2004.05.005

PMID:15246424

Abstract

A recent study shows that the RASSF1A tumor suppressor functions as a regulator of the ordered proteolytic steps that organize mitosis. By controlling the stability of microtubules and the activity of the anaphase-promoting complex (APC), RASSF1A might provide a crucial link between mechanisms of tumor suppression and mitotic cell division. Furthermore, another recent study shows that protein kinase A, which is a key growth regulator, inhibits the APC during mitosis in yeast.

摘要

最近的一项研究表明，RASSF1A肿瘤抑制因子作为组织有丝分裂的有序蛋白水解步骤的调节因子发挥作用。通过控制微管的稳定性和后期促进复合物（APC）的活性，RASSF1A可能在肿瘤抑制机制和有丝分裂细胞分裂之间提供关键联系。此外，另一项最近的研究表明，作为关键生长调节因子的蛋白激酶A在酵母有丝分裂期间抑制APC。