Farrer Chloe, Franck Nicolas, Frith Chris D, Decety Jean, Georgieff Nicolas, d'Amato Thierry, Jeannerod Marc
Institut des Sciences Cognitives, 67 boulevard Pinel, 69675 Bron Cedex, France.
Psychiatry Res. 2004 May 30;131(1):31-44. doi: 10.1016/j.pscychresns.2004.02.004.
Patients with first-rank symptoms (FRS) of schizophrenia do not experience all of their actions and personal states as their own. FRS may be associated with an impaired ability to correctly attribute an action to its origin. In the present study, we examined regional cerebral blood flow (rCBF) with positron emission tomography during an action-attribution task in a group of patients with FRS. We used a device previously used with healthy subjects that allows the experimenter to modulate the subject's degree of movement control (and thus action attribution) of a virtual hand presented on a screen. In healthy subjects, the activity of the right angular gyrus and the insula cortex appeared to be modulated by the subject's degree of movement control of the virtual hand. In the present study, the schizophrenic patients did not show this pattern. We found an aberrant relationship between the subject's degree of control of the movements and rCBF in the right angular gyrus and no modulation in the insular cortex. The implications of these results for understanding pathological conditions such as schizophrenia are discussed.
患有精神分裂症一级症状（FRS）的患者并不将自己的所有行为和个人状态体验为属于自己的。FRS可能与正确将一个行为归因于其源头的能力受损有关。在本研究中，我们在一组患有FRS的患者进行动作归因任务期间，使用正电子发射断层扫描检查了局部脑血流量（rCBF）。我们使用了一种先前用于健康受试者的设备，该设备允许实验者调节受试者对屏幕上呈现的虚拟手的运动控制程度（从而调节动作归因）。在健康受试者中，右侧角回和岛叶皮质的活动似乎受到受试者对虚拟手的运动控制程度的调节。在本研究中，精神分裂症患者未表现出这种模式。我们发现受试者的运动控制程度与右侧角回的rCBF之间存在异常关系，且岛叶皮质无调节作用。讨论了这些结果对理解精神分裂症等病理状况的意义。
