Bomba Marie D, Pang Elizabeth W
Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada.
Int J Psychophysiol. 2004 Aug;53(3):161-9. doi: 10.1016/j.ijpsycho.2004.04.001.
The question of etiology in autism remains elusive primarily due to the fact that autism does not result from a single dysfunction but is multi-faceted in nature. Investigations into etiology have ranged from identifying abnormalities in the genome to describing structural/functional brain abnormalities. Bearing in mind the risk of over-simplification, there is still utility in isolating a specific deficit to examine its etiologic contribution. It is known that individuals with autism have difficulty processing auditory information at the cortical level but this is not consistently seen subcortically. In recent years, cortical auditory processing has been extensively researched using event-related potentials (ERPs); however, these results in relation to autism have not been reviewed. This paper will examine this literature and discuss implications for future research.
自闭症的病因问题仍然难以捉摸,主要是因为自闭症并非由单一功能障碍引起,而是具有多方面的性质。对病因的研究范围从确定基因组中的异常到描述大脑结构/功能异常。尽管要注意过度简化的风险,但分离出一种特定缺陷以检查其病因贡献仍有一定作用。已知自闭症患者在皮层水平处理听觉信息有困难,但在皮层下却并非始终如此。近年来,利用事件相关电位(ERP)对皮层听觉处理进行了广泛研究;然而,这些与自闭症相关的结果尚未得到综述。本文将审视这方面的文献,并讨论对未来研究的启示。