Galimard N, Vassilev K, Chevignard M, Perrigot M, Mazevet D
Service de Médecine Physique et de Réadaptation, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Rev Neurol (Paris). 2004 Jul;160(6-7):672-7. doi: 10.1016/s0035-3787(04)71017-6.
Muscular hematomas are frequently reported as a complication of anticoagulation therapy.
We report six cases of spontaneous muscular hematomas occurring in hemiplegic patients receiving anticoagulation therapy using heparin, low-molecular-weight heparin or fluindione. Anticoagulation therapy was given in prophylactic doses to two patients to prevent deep vein thrombosis and in therapeutic doses to four patients with deep vein thrombosis, pulmonary embolism or cardiac arrhythmia. Two patients experienced episodes of bleeding when heparin and fluindione were temporarily associated.
Contrary to previous reports, the more frequent site of bleeding was not the ilio-psoas muscle (only 2 patients); hematomas were also observed in hip adductors and gluteus muscles. The most striking finding was the constant location of the hematoma on the hemiplegic side.
Location on the hemiplegic side can lead to underestimating the frequency of neurologic compression by the hematoma; the diagnosis can nevertheless be established by electromyography. Local signs may not be present, but general signs of hypovolemia and anemia are more frequent. Ultrasound may be the first line investigation but in our experience, the results can be misleading and computed tomography (CT) or MRI are often required to confirm the diagnosis.
肌肉血肿常被报道为抗凝治疗的并发症。
我们报告6例接受肝素、低分子肝素或氟茚二酮抗凝治疗的偏瘫患者发生自发性肌肉血肿的病例。2例患者接受预防性剂量的抗凝治疗以预防深静脉血栓形成,4例患有深静脉血栓形成、肺栓塞或心律失常的患者接受治疗性剂量的抗凝治疗。2例患者在肝素和氟茚二酮临时联合使用时出现出血事件。
与先前报道相反,出血较常见的部位不是髂腰肌(仅2例患者);在髋内收肌和臀肌中也观察到血肿。最显著的发现是血肿始终位于偏瘫侧。
血肿位于偏瘫侧可能导致低估其对神经压迫的发生率;然而,通过肌电图检查仍可确诊。可能不存在局部体征,但血容量不足和贫血的全身体征更为常见。超声检查可能是首选的检查方法,但根据我们的经验,其结果可能会产生误导,通常需要计算机断层扫描(CT)或磁共振成像(MRI)来确诊。