Madhi Shabir A, Klugman Keith P
University of the Witwatersrand/Medical Research Council/National Institute for Communicable Diseases Respiratory and Meningeal Pathogens Research Unit, Atlanta 30332, USA.
Nat Med. 2004 Aug;10(8):811-3. doi: 10.1038/nm1077. Epub 2004 Jul 11.
Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15-43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia.
在南非索韦托对37107名完全免疫的婴儿进行的一项双盲、随机、安慰剂对照试验中,我们发现一种9价肺炎球菌结合疫苗(PncCV)可预防住院儿童中31%(95%置信区间 = 15 - 43%)与七种呼吸道病毒中任何一种相关的肺炎。这些数据表明,肺炎球菌在与这些病毒相关的肺炎发展中起主要作用,并且病毒有助于细菌性肺炎的发病机制。