Lanzafame Massimiliano, Faggian Federica, Lattuada Emanuela, Antolini Dario, Concia Ercole
Divisione Clinicizzata di Malattie Infettive, Ospedale Civile Maggiore Borgo Trento, Verona.
Recenti Prog Med. 2004 Jun;95(6):312-3.
Lipodystrophy in patients with HIV-infection has been studied intensively to understand its epidemiology and pathophysiology. Recently its development was attributed to a dysregulation of TNF-alpha synthesis' homeostasis by HAART. A few years ago it was found that pentoxifylline decreases TNF-alpha production. We describe one HIV-infected patient, with lipodystrophy syndrome, treated with pentoxifylline without any improvement of lipodystrophic symptoms.
为了解其流行病学和病理生理学，对HIV感染患者的脂肪代谢障碍进行了深入研究。最近，其发展被归因于高效抗逆转录病毒治疗（HAART）导致的肿瘤坏死因子-α（TNF-α）合成稳态失调。几年前发现己酮可可碱可降低TNF-α的产生。我们描述了一名患有脂肪代谢障碍综合征的HIV感染患者，用己酮可可碱治疗后脂肪代谢障碍症状未得到任何改善。
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