Fas信号通路及其在癌症发病机制中的作用。

The Fas signalling pathway and its role in the pathogenesis of cancer.

作者信息

Houston Aileen, O'Connell Joe

机构信息

Department of Medicine, Clinical Sciences Building, National University of Ireland, University Hospital, Cork, Ireland.

出版信息

Curr Opin Pharmacol. 2004 Aug;4(4):321-6. doi: 10.1016/j.coph.2004.03.008.

DOI:10.1016/j.coph.2004.03.008

PMID:15251123

Abstract

Tumor cells frequently exhibit de novo expression of Fas ligand (FasL/CD95L). Coupled with resistance to Fas-mediated apoptosis, FasL expression enables many cancers to deliver a pre-emptive strike or 'counterattack' against the immune system. New studies also indicate that FasL expression on tumor cells could confer a double advantage to these cells by stimulating their own proliferation. However, pro-inflammatory effects of FasL have also been observed. New findings are beginning to reconcile the paradoxical effects of FasL, with the clinical significance of the Fas counterattack only beginning to emerge.

摘要

肿瘤细胞常常表现出Fas配体（FasL/CD95L）的从头表达。加上对Fas介导的细胞凋亡具有抗性，FasL的表达使许多癌症能够对免疫系统发动先发制人的打击或“反击”。新的研究还表明，肿瘤细胞上的FasL表达可通过刺激其自身增殖而赋予这些细胞双重优势。然而，也观察到了FasL的促炎作用。新的发现开始调和FasL的矛盾效应，而Fas反击的临床意义才刚刚开始显现。