糖尿病视网膜病变中通过彩色多普勒成像测定的眼血流速度

Ocular blood flow velocity determined by color Doppler imaging in diabetic retinopathy.

作者信息

Gracner Tomaz

机构信息

Department of Ophthalmology, Maribor Teaching Hospital, Maribor, Slovenia.

出版信息

Ophthalmologica. 2004 Jul-Aug;218(4):237-42. doi: 10.1159/000078613.

DOI:10.1159/000078613

PMID:15258411

Abstract

PURPOSE

To measure and investigate changes of blood flow velocity by color Doppler imaging in the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (PCA) in diabetic retinopathy (DR) and to compare the results with those in healthy control subjects.

METHODS

In this investigation we included 44 eyes of 44 diabetic patients with different stages of DR forming group NPDR (11 eyes with mild and 11 eyes with moderate nonproliferative DR) and group SNPDR/PDR (19 eyes with severe nonproliferative and 3 eyes with proliferative DR) and 22 eyes of 22 healthy age- and sex-matched subjects forming control group HC. With color Doppler imaging we measured the peak systolic velocity (PSV, cm/s) and end-diastolic velocity (EDV, cm/s) of blood flow in the OA, CRA and PCA. The resistance index of each vessel was then calculated. Statistical analysis comparing the results of groups NPDR, SNPDR/PDR and HC was carried out. Statistical significance was set at p < 0.05.

RESULTS

There was a statistically significant increase in PSV in the OA in group SNPDR/PDR compared with group HC (35.71 +/- 6.90 vs. 31.45 +/- 4.32 cm/s; mean +/- SD). There was a statistically significant decrease in PSV in the CRA in group NPDR compared with group HC (8.50 +/- 1.62 vs. 10.61 +/- 1.75 cm/s; mean +/- SD) and in group SNPDR/PDR compared with group HC (7.34 +/- 1.78 vs. 10.61 +/- 1.75 cm/s; mean +/- SD), also there was a statistically significant decrease in EDV in group SNPDR/PDR compared with group HC (2.05 +/- 0.53 vs. 3.00 +/- 0.81 cm/s; mean +/- SD). A statistically significant decrease in EDV in the PCA in group SNPDR/PDR compared with group HC (2.95 +/- 1.04 vs. 3.95 +/- 0.98 cm/s; mean +/- SD) was found, also there was a statistically significant increase in the resistance index in group SNPDR/PDR compared with group NPDR (0.72 +/- 0.05 vs. 0.67 +/- 0.07; mean +/- SD) and in group SNPDR/PDR compared with group HC (0.72 +/- 0.05 vs. 0.67 +/- 0.05; mean +/- SD).

CONCLUSIONS

In this investigation, color Doppler imaging was used to determine significant changes of blood flow velocity in the OA, CRA and PCA in DR compared with healthy control subjects and the changes of blood flow velocity become further significant considering the progression of DR. This points to the presence of circulatory changes in the OA, CRA and PCA in diabetic patients with DR.

摘要

目的

通过彩色多普勒成像测量并研究糖尿病视网膜病变（DR）患者眼动脉（OA）、视网膜中央动脉（CRA）和睫状后短动脉（PCA）的血流速度变化，并将结果与健康对照者进行比较。

方法

本研究纳入44例不同阶段DR糖尿病患者的44只眼，分为非增殖性DR组（NPDR，轻度11只眼、中度非增殖性DR 11只眼）和重度非增殖性/增殖性DR组（SNPDR/PDR，重度非增殖性19只眼、增殖性DR 3只眼），以及22例年龄和性别匹配的健康受试者的22只眼作为健康对照组（HC）。采用彩色多普勒成像测量OA、CRA和PCA血流的收缩期峰值速度（PSV，cm/s）和舒张末期速度（EDV，cm/s）。然后计算各血管的阻力指数。对NPDR组、SNPDR/PDR组和HC组的结果进行统计学分析。设定统计学显著性水平为p<0.05。

结果

与HC组相比，SNPDR/PDR组OA的PSV有统计学显著升高（35.71±6.90 vs. 31.45±4.32 cm/s；均值±标准差）。与HC组相比，NPDR组CRA的PSV有统计学显著降低（8.50±1.62 vs. 10.61±1.75 cm/s；均值±标准差），SNPDR/PDR组CRA的PSV也有统计学显著降低（7.34±1.78 vs. 10.61±1.75 cm/s；均值±标准差），与HC组相比，SNPDR/PDR组的EDV也有统计学显著降低（2.05±0.53 vs. 3.00±0.81 cm/s；均值±标准差）。与HC组相比，SNPDR/PDR组PCA的EDV有统计学显著降低（2.95±1.04 vs. 3.95±0.98 cm/s；均值±标准差），与NPDR组相比，SNPDR/PDR组的阻力指数有统计学显著升高（0.72±0.05 vs. 0.67±0.07；均值±标准差），与HC组相比，SNPDR/PDR组的阻力指数也有统计学显著升高（0.72±0.05 vs. 0.67±0.05；均值±标准差）。