Shotton J C, Gresty M G, Ludman H, Metcalfe T
Medical Research Council Human Movement and Balance Unit, National Hospital for Nervous Diseases, London, UK.
Clin Otolaryngol Allied Sci. 1992 Aug;17(4):332-6. doi: 10.1111/j.1365-2273.1992.tb01007.x.
A clinical and vestibulometric comparison of 10 patients following labyrinthectomy, 5 following vestibular nerve section, and 10 control subjects was undertaken in order to evaluate the long-term effectiveness of these procedures. Testing was performed a mean of 8.5 years after surgery. Vestibulometry assessed time constants, gain, and phase advance of the vestibulo-ocular reflex (VOR) in both horizontal and vertical planes of head movement. Loss of the anticipated increase in phase advance in the vertical VOR of the labyrinthectomy group, significantly different from the vestibular nerve section group (P less than 0.05 and P less than 0.01 for each direction of rotation), suggests that posterior and superior semicircular canal function remains intact following per-meatal labyrinthectomy. Although stabilometry suggested that balance in the labyrinthectomy group was poorer than in the two other groups (P less than 0.025 without optic fixation), clinical assessment demonstrated excellent functional results. Per-meatal labyrinthectomy remains a safe and effective procedure for the relief of vestibular symptoms, although vestibular nerve section may provide more complete removal of contributory end-organ function.
为评估迷宫切除术、前庭神经切断术的长期效果,对10例迷宫切除术后患者、5例前庭神经切断术后患者和10例对照受试者进行了临床和前庭功能测定比较。测试在术后平均8.5年进行。前庭功能测定评估了头部运动水平和垂直平面上前庭眼反射(VOR)的时间常数、增益和相位超前。迷宫切除术后组垂直VOR相位超前预期增加量的丧失,与前庭神经切断术组有显著差异(每个旋转方向P均小于0.05和P小于0.01),这表明经耳道迷宫切除术后后半规管和上半规管功能仍保持完整。尽管稳定测量法表明迷宫切除术后组的平衡比其他两组差(无视觉固定时P小于0.025),但临床评估显示功能结果良好。经耳道迷宫切除术仍然是缓解前庭症状的一种安全有效的手术,尽管前庭神经切断术可能能更彻底地消除相关终器功能。