在自发性高血压大鼠中，神经生长因子信使核糖核酸的含量与交感神经支配的改变平行。

Nerve growth factor mRNA content parallels altered sympathetic innervation in the spontaneously hypertensive rat.

Falckh P H, Harkin L A, Head R J

CSIRO Division of Human Nutrition, Adelaide, South Australia.

Clin Exp Pharmacol Physiol. 1992 Aug;19(8):541-5. doi: 10.1111/j.1440-1681.1992.tb00502.x.

Abstract

In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins obtained from SHR when compared with the contents of NGFmRNA in veins from Wistar Kyoto rats (WKY). 3. The NGFmRNA content of kidneys was greater in SHR when compared with the levels present in WKY rats for 10- and 43-day-old animals. 4. In contrast to the pattern observed for veins and kidneys, the NGFmRNA content of SHR hearts was smaller than those present in hearts from WKY rats for 2, 10 and 43-day-old animals. 5. The results demonstrate that tissues with enhanced innervation (the kidney and mesenteric vasculature) in SHR are associated with an enhanced expression of NGFmRNA. In contrast, the heart, which does not display an enhanced sympathetic innervation in the SHR, does not have an increased expression of NGFmRNA. 6. It is suggested that in the SHR there is a tight relationship between hypernoradrenergic innervation in the vasculature and gene expression for NGFmRNA.

摘要

为了探究自发性高血压大鼠（SHR）血管中去甲肾上腺素能神经支配增强的机制，检测了神经生长因子信使核糖核酸（NGFmRNA）的组织含量。2. 与Wistar Kyoto大鼠（WKY）静脉中的NGFmRNA含量相比，SHR肠系膜静脉中NGFmRNA的浓度显著升高。3. 对于10日龄和43日龄的动物，SHR肾脏中的NGFmRNA含量高于WKY大鼠。4. 与静脉和肾脏中观察到的模式相反，对于2日龄、10日龄和43日龄的动物，SHR心脏中的NGFmRNA含量低于WKY大鼠心脏中的含量。5. 结果表明，SHR中神经支配增强的组织（肾脏和肠系膜血管）与NGFmRNA表达增强相关。相反，在SHR中未表现出交感神经支配增强的心脏，其NGFmRNA表达并未增加。6. 提示在SHR中，血管中去甲肾上腺素能神经支配增强与NGFmRNA的基因表达之间存在紧密关系。