Reichardt Louis F, Mobley William C
Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, 1550 Fourth Street, Room 284A, San Francisco, CA 94143, USA.
Cell. 2004 Jul 23;118(2):141-3. doi: 10.1016/j.cell.2004.07.008.
NGF and NT-3 both signal through TrkA receptors on the axons of developing sympathetic neurons, but while NGF supports survival and differentiation, NT-3 does not. In this issue of Cell, the difference is explained as the ability of NGF, but not NT-3, to induce internalization and retrograde transport of activated TrkA.
神经生长因子（NGF）和神经营养素-3（NT-3）都通过发育中的交感神经元轴突上的酪氨酸激酶A（TrkA）受体发出信号，但NGF能支持神经元存活和分化，而NT-3则不能。在本期《细胞》杂志中，这种差异被解释为NGF而非NT-3具有诱导活化的TrkA内化和逆向运输的能力。
