神经营养因子信号传导的远近问题

Going the distance, or not, with neurotrophin signals.

作者信息

Reichardt Louis F, Mobley William C

机构信息

Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, 1550 Fourth Street, Room 284A, San Francisco, CA 94143, USA.

出版信息

Cell. 2004 Jul 23;118(2):141-3. doi: 10.1016/j.cell.2004.07.008.

DOI:10.1016/j.cell.2004.07.008

PMID:15260984

Abstract

NGF and NT-3 both signal through TrkA receptors on the axons of developing sympathetic neurons, but while NGF supports survival and differentiation, NT-3 does not. In this issue of Cell, the difference is explained as the ability of NGF, but not NT-3, to induce internalization and retrograde transport of activated TrkA.

摘要

神经生长因子（NGF）和神经营养素-3（NT-3）都通过发育中的交感神经元轴突上的酪氨酸激酶A（TrkA）受体发出信号，但NGF能支持神经元存活和分化，而NT-3则不能。在本期《细胞》杂志中，这种差异被解释为NGF而非NT-3具有诱导活化的TrkA内化和逆向运输的能力。