双子表面活性剂对流体片层相鸡蛋磷脂酰胆碱双层膜的影响。

Effects of gemini surfactants on egg phosphatidylcholine bilayers in the fluid lamellar phase.

作者信息

Dubnicková Martina, Yaradaikin Sergej, Lacko Ivan, Devínsky Ferdinand, Gordeliy Valentin, Balgavý Pavol

机构信息

Faculty of Pharmacy, Comenius University, 83232 Bratislava, Slovak Republic.

出版信息

Colloids Surf B Biointerfaces. 2004 Apr 1;34(3):161-4. doi: 10.1016/j.colsurfb.2003.12.009.

DOI:10.1016/j.colsurfb.2003.12.009

PMID:15261069

Abstract

The influence of 1,4-butanediamonium-N,N'-dialkyl-N,N,N',N'-tetramethyl dibromides (CmA, m = 7-16 is the number of alkyl carbons) on the egg yolk phosphatidylcholine (EYPC) bilayer thickness and lipid surface area at the bilayer-aqueous phase interface is studied using X-ray diffraction on fluid lamellar CmA + EYPC + H2O phases as a function of CmA:EYPC and H2O:EYPC molar ratios and the alkyl chain length m. At the constant CmA:EYPC = 0.4 and H2O:EYPC = 18 molar ratios, the CmA induced bilayer thickness decrease shows a minimum and the lipid surface area increase a maximum at the alkyl chain length m = 9. The obtained results are discussed in the context of a structural perturbation model of the cut-off effect in biological potencies of surfactants which occurs when increasing the alkyl substituent chain length above the critical value.

摘要

利用X射线衍射研究了1,4 - 丁二铵 - N,N'-二烷基 - N,N,N',N'-四甲基二溴化物（CmA，m = 7 - 16为烷基碳原子数）对卵黄磷脂酰胆碱（EYPC）双层厚度以及双层 - 水相界面处脂质表面积的影响，该研究以流体片层CmA + EYPC + H₂O相作为CmA:EYPC和H₂O:EYPC摩尔比以及烷基链长度m的函数。在恒定的CmA:EYPC = 0.4和H₂O:EYPC = 18摩尔比下，CmA诱导的双层厚度减小在烷基链长度m = 9时显示出最小值，而脂质表面积增加显示出最大值。在表面活性剂生物活性的截止效应的结构扰动模型的背景下讨论了所得结果，当烷基取代链长度增加到临界值以上时会出现这种截止效应。