Morerio Cristina, Rapella Annamaria, Rosanda Cristina, Lanino Edoardo, Lo Nigro Luca, Di Cataldo Andrea, Maserati Emanuela, Pasquali Francesco, Panarello Claudio
Dipartimento di Ematologia ed Oncologia Pediatrica, Istituto Giannina Gaslini, L.go G. Gaslini 5, 16148 Genova, Italy.
Cancer Genet Cytogenet. 2004 Jul 15;152(2):108-12. doi: 10.1016/j.cancergencyto.2003.11.012.
Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.
呈现MLL-MLLT10（别名MLL-AF10）融合的急性单核细胞白血病病例的细胞遗传学研究显示染色体断点具有广泛的异质性。我们报告了两例新的伴有MLL-MLLT10融合的儿童病例（法美英分型M5），并用荧光原位杂交技术对其进行了研究。在这两例病例中，我们均检测到11q区域的臂间倒位，该倒位片段易位至10号染色体的p12区；其中1例显示出变异的复杂模式。我们回顾了有关11q近端倒位断点的细胞遗传学分子数据，并证实了其异质性。
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