台湾青少年特发性关节炎患者的 HLA-DRB1 基因分型

HLA-DRB1 genotyping in patients with juvenile idiopathic arthritis in Taiwan.

作者信息

Huang J-L, Yeh C-C, Shaw C-K, Yao T-C, Chen L-C, Lee T-D, Kuo M-L

机构信息

Department of Pediatrics, Chang Gung University and Chang Gung Children's Hospital, Taoyuan, Taiwan.

出版信息

Eur J Immunogenet. 2004 Aug;31(4):185-8. doi: 10.1111/j.1365-2370.2004.00467.x.

DOI:10.1111/j.1365-2370.2004.00467.x

PMID:15265024

Abstract

The object of this study was to investigate whether there is an association between HLA-DRB1 alleles and the development of juvenile idiopathic arthritis (JIA) in Taiwan. HLA-DRB1 alleles were studied in 60 patients with JIA and 200 healthy controls using polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (SSO). The frequency of HLA-DRB10405 in patients with JIA was found to be significantly higher than that in healthy controls [odds ratio (OR) 2.64, 95% confidence interval (CI) 1.01-6.91]. The DRB10405 allele was significantly associated with the development of both polyarthritis (OR 4.30, 95% CI 1.34-13.80) and oligoarthritis (OR 3.27, 95% CI 1.01-10.58). The frequency of HLA-DRB11502 was higher in Taiwanese JIA patients with systemic arthritis than in controls (OR 18.09, 95% CI 2.25-145.73). We conclude that, in Taiwan, HLA-DRB10405 is associated with the development of polyarthritis and oligoarthritis in children, and HLA-DRB1*1502 is associated with the development of systemic arthritis.

摘要

本研究的目的是调查台湾地区人类白细胞抗原-DRB1（HLA-DRB1）等位基因与幼年特发性关节炎（JIA）发病之间是否存在关联。采用聚合酶链反应（PCR）/序列特异性寡核苷酸探针（SSO）技术，对60例JIA患者和200名健康对照者的HLA-DRB1等位基因进行研究。结果发现，JIA患者中HLA-DRB10405的频率显著高于健康对照者[优势比（OR）2.64，95%置信区间（CI）1.01 - 6.91]。DRB10405等位基因与多关节炎（OR 4.30，95% CI 1.34 - 13.80）和少关节炎（OR 3.27，95% CI 1.01 - 10.58）的发病均显著相关。台湾地区患全身型关节炎的JIA患者中HLA-DRB11502的频率高于对照组（OR 18.09，95% CI 2.25 - 145.73）。我们得出结论，在台湾地区，HLA-DRB10405与儿童多关节炎和少关节炎的发病相关，而HLA-DRB1*1502与全身型关节炎的发病相关。