恒河猴双侧额叶眼区损伤对快速眼动睡眠期间快速眼动的年龄相关影响。
Age-related effects of bilateral frontal eye fields lesions on rapid eye movements during REM sleep in rhesus monkeys.
作者信息
Yu Shan, Liu Ning, Zeng Tao, Tian Shaohua, Chen Nanhui, Zhou Yifeng, Ma Yuanye
机构信息
School of Life Sciences, University of Science and Technology of China, Hefei, PR China.
出版信息
Neurosci Lett. 2004 Aug 5;366(1):58-62. doi: 10.1016/j.neulet.2004.05.011.
Rapid eye movement (REM) is one of the most characteristic features of REM sleep, but the mechanisms underlying its regulation remain unclear. The present study aims to investigate whether the frontal eye field (FEF) is involved in the regulation of the rapid eye movements during REM sleep. To address this question, we ablated the FEF in four rhesus monkeys and observed the effects of the lesions on sleep architecture. After lesions, two adult monkeys did not show any lesion effect. However, in the other two adolescent monkeys, both the total duration and percentage of the rapid eye movements during REM sleep were decreased moderately. The result suggests that the relation between the FEF and the regulation of the rapid eye movements during REM sleep may be affected by age factor, also indicating that both the functions of the FEF and the mechanisms underlying the control of rapid eye movements during REM sleep might not be the same throughout the whole life span of an animal.
快速眼动（REM）是快速眼动睡眠最具特征性的特点之一，但其调节机制仍不清楚。本研究旨在调查额叶眼区（FEF）是否参与快速眼动睡眠期间快速眼动的调节。为了解决这个问题，我们在四只恒河猴中损毁了FEF，并观察损伤对睡眠结构的影响。损伤后，两只成年猴子未表现出任何损伤效应。然而，在另外两只青春期猴子中，快速眼动睡眠期间快速眼动的总时长和百分比均有适度下降。结果表明，FEF与快速眼动睡眠期间快速眼动调节之间的关系可能受年龄因素影响，这也表明FEF的功能以及快速眼动睡眠期间快速眼动控制的潜在机制在动物的整个生命周期中可能并不相同。
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