Ozelo Margareth C, Origa Andrea F, Aranha Francisco J P, Mansur Antonio P, Annichino-Bizzacchi Joyce M, Costa Fernando F, Pollak Eleanor S, Arruda Valder R
State University of Campinas, Brazil.
Thromb Haemost. 2004 Aug;92(2):384-6. doi: 10.1160/TH03-12-0744.
Platelet glycoprotein Iba (GPIba) gene polymorphisms have been reported to affect the risk of developing coronary heart disease. Here, within the GPIba gene, we determine the association between the variable number of tandem repeats (VNTR), the -5C/T Kozak sequence dimorphism, and the human platelet antigen (HPA)-2 polymorphisms with occurrence of myocardial infarction (MI). Patients (n=180) presenting survivors of MI were compared to 180 controls matched by age, gender, and race. Carriers of VNTR-CD genotype had a 2-fold higher risk for MI compared to controls. The prevalence of VNTR-BC was lower among patients than among controls (P=.007). These data are in agreement with recent reports of increased plug formation by human platelets containing VNTRCD but no other VNTR genotypes. Among patients, the number of vessels severely occluded was greater among carriers of the D-allele (P=.019) or VNTR-CD (P=.026) and lower among carriers of the C-allele (P=.003) or VNTR-CC (P=.0009) compared to non-carriers of these alleles. No influence was seen with the Kozak or HPA-2 polymorphisms. Determination of VNTR of the GPIba gene may prove useful for identifying high-risk individuals for MI.
据报道，血小板糖蛋白Iba（GPIba）基因多态性会影响冠心病的发病风险。在此，我们在GPIba基因中确定串联重复序列（VNTR）数量可变、-5C/T Kozak序列二态性以及人类血小板抗原（HPA）-2多态性与心肌梗死（MI）发生之间的关联。将180例MI存活患者与180例年龄、性别和种族相匹配的对照进行比较。与对照组相比，VNTR-CD基因型携带者发生MI的风险高2倍。患者中VNTR-BC的患病率低于对照组（P = 0.007）。这些数据与最近关于含有VNTRCD但无其他VNTR基因型的人类血小板血栓形成增加的报道一致。在患者中，与这些等位基因的非携带者相比，D等位基因携带者（P = 0.019）或VNTR-CD携带者（P = 0.026）中严重闭塞血管的数量更多，而C等位基因携带者（P = 0.003）或VNTR-CC携带者（P = 0.0009）中严重闭塞血管的数量更少。未发现Kozak或HPA-2多态性有影响。确定GPIba基因的VNTR可能有助于识别MI的高危个体。
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