复发性外阴佩吉特病中p185HER2过表达与HER2癌基因扩增

p185HER2 overexpression and HER2 oncogene amplification in recurrent vulvar Paget's disease.

作者信息

Reich Olaf, Liegl Bernadette, Tamussino Karl, Regauer Sigrid

机构信息

Department of Obstetrics and Gynecology, Medical University of Graz, Austria.

出版信息

Mod Pathol. 2005 Mar;18(3):354-7. doi: 10.1038/modpathol.3800243.

DOI:10.1038/modpathol.3800243

PMID:15272283

Abstract

We evaluated p186Her2 overexpression and HER2 oncogene amplification in recurrent vulvar Paget's disease. We identified six patients with recurrent vulvar Paget's disease in our archives. The number of recurrences ranged from 1 to 11 over a time period of 1-168 months. Recurrences were evaluated immunohistochemically for p185Her2 overexpression with the HercepTest and for HER2 oncogene amplification with fluorescence in situ hybridization. p185Her2 overexpression was scored as 3 in two patients, as 2 in two patients, and as 1 in two patients. All patients with scores 2 and 3 showed HER2 oncogene amplification. Overexpression of p185Her2 and HER2 oncogene amplification appears to be common in recurrent vulvar Paget's disease.

摘要

我们评估了复发性外阴佩吉特病中p186Her2过表达和HER2癌基因扩增情况。我们在档案中识别出6例复发性外阴佩吉特病患者。复发次数在1至11次之间，时间跨度为1至168个月。采用HercepTest免疫组化法评估复发灶中p185Her2过表达情况，采用荧光原位杂交法评估HER2癌基因扩增情况。2例患者p185Her2过表达评分为3分，2例患者评分为2分，2例患者评分为1分。所有评分为2分和3分的患者均显示HER2癌基因扩增。p185Her2过表达和HER2癌基因扩增在复发性外阴佩吉特病中似乎很常见。