动质体DNA的组装。

The assembly of kinetoplast DNA.

作者信息

Shlomai J

机构信息

Department of Parasitology, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel.

出版信息

Parasitol Today. 1994 Sep;10(9):341-6. doi: 10.1016/0169-4758(94)90244-5.

DOI:10.1016/0169-4758(94)90244-5

PMID:15275411

Abstract

The unusual structure of the kinetoplast DNA (kDNA) of trypanosomatids requires unique replication mechanisms. Deciphering the mechanisms that regulate the network assembly has been a challenge for many years. A better understanding of these processes was facilitated by recent studies on the fine structure of resting and replicating kDNA networks. In this review, Joseph Shlomai discusses our current view of the structural and mechanistic aspects of the assembly of kinetoplast DNA.

摘要

锥虫的动基体DNA（kDNA）的特殊结构需要独特的复制机制。多年来，破译调控网络组装的机制一直是一项挑战。最近关于静止和复制的kDNA网络精细结构的研究有助于更好地理解这些过程。在这篇综述中，约瑟夫·什洛迈讨论了我们目前对动基体DNA组装的结构和机制方面的看法。