Safi S, Hassikou H, Messary A, Boumdin H, Hadri L, Zouhair A
Service de médecin interne, hôpital militaire Moulay Ismaïl, Meknès.
Ann Endocrinol (Paris). 2004 May;65(3):226-32. doi: 10.1016/s0003-4266(04)95677-6.
Primary hyperparathyrodism is a common disease, often asymptomatic. A young post-partum woman was hospitalized for functional impotence of the upper right limb and poor health status. Laboratory tests revealed severe primary hyperparathyroidism (osteitis fibrosa cystica and nephrolithiasis) associated with vitamin D deficiency. Technetium 99m and thallium parathyroid scintigraphy showed increased uptake under the left thyroid lobe. After surgical resection of a parathyroid adenoma, serum calcium fell markedly and parathyroid levels declined but remained above normal. Calcium and 25(OH)-vitamin D supplementation led to normal calcium and vitamin D levels in three Months, with marked improvement in the bone lesions visualized on the six-Month x-rays. Based on this observation, we describe the many radiological aspects of bone involvement in long-standing hyperparathyroidism aggravated by vitamin D deficiency. Early diagnosis of hyperparathyroidism is crucial.
原发性甲状旁腺功能亢进是一种常见疾病,通常无症状。一名年轻的产后女性因右上肢体功能障碍和健康状况不佳而住院。实验室检查显示严重的原发性甲状旁腺功能亢进(纤维囊性骨炎和肾结石)伴有维生素D缺乏。锝99m和铊甲状旁腺闪烁扫描显示左甲状腺叶下方摄取增加。手术切除甲状旁腺腺瘤后,血清钙明显下降,甲状旁腺水平降低但仍高于正常。补充钙和25(OH)-维生素D三个月后钙和维生素D水平恢复正常,六个月X线显示骨病变明显改善。基于这一观察结果,我们描述了因维生素D缺乏而加重的长期甲状旁腺功能亢进症中骨受累的诸多放射学表现。甲状旁腺功能亢进的早期诊断至关重要。