抗转移钌（III）配合物[ImH][RuCl(4)(DMSO)(Im)]（NAMI-A）的氧化还原行为评估

Appraisal of the redox behaviour of the antimetastatic ruthenium(III) complex [ImH][RuCl(4)(DMSO)(Im)], NAMI-A.

作者信息

Ravera Mauro, Baracco Sara, Cassino Claudio, Zanello Piero, Osella Domenico

机构信息

Dipartimento di Scienze dell'Ambiente e della Vita, Universita del Piemonte Orientale "Amedeo Avogadro", Spalto Marengo 33, 15100 Alessandria, Italy.

出版信息

Dalton Trans. 2004 Aug 7(15):2347-51. doi: 10.1039/b400952E. Epub 2004 Jun 29.

DOI:10.1039/b400952E

PMID:15278129

Abstract

The imidazolium trans-tetrachloro(dimethylsulfoxide)imidazoleruthenate(III) complex [ImH][Ru(III)Cl(4)(DMSO)(Im)], NAMI-A, has shown an interesting antimetastatic activity. Since Ru(III) complexes are coordinatively more inert than the corresponding Ru(II) derivatives, an "activation by reduction" mechanism has been proposed to explain the biological activity of NAMI-A, thus acting as a pro-drug. We report here an electrochemical study on NAMI-A in aqueous solutions which emphasizes the structural and chemical consequences accompanying the easy Ru(III)/Ru(II) electron transfer (e.g., axial imidazole/water exchange in acidic solution in the short timescale of cyclic voltammetry followed by equatorial chloride/water exchange in the longer timescale of macroelectrolysis).

摘要

咪唑钌（III）反式四氯（二甲亚砜）咪唑配合物[ImH][Ru(III)Cl₄(DMSO)(Im)]，即NAMI-A，已显示出有趣的抗转移活性。由于Ru(III)配合物在配位方面比相应的Ru(II)衍生物更惰性，因此提出了一种“还原激活”机制来解释NAMI-A的生物活性，从而使其作为前药发挥作用。我们在此报告了一项关于NAMI-A在水溶液中的电化学研究，该研究强调了伴随Ru(III)/Ru(II)容易发生电子转移所产生的结构和化学后果（例如，在循环伏安法的短时间尺度下，酸性溶液中轴向咪唑/水发生交换，随后在宏观电解的较长时间尺度下，赤道面的氯/水发生交换）。