静脉注射利多卡因对猫肺迷走传入神经和膈神经活动的影响。

Effects of intravenously administered lidocaine on pulmonary vagal afferents and phrenic nerve activity in cats.

作者信息

Aoki M, Harada Y, Namiki A, Ikeda M, Shimizu H

机构信息

Department of Anesthesiology, Sapporo Medical College, Sapporo, Japan.

出版信息

J Anesth. 1992 Oct;6(4):395-400. doi: 10.1007/s0054020060395.

DOI:10.1007/s0054020060395

PMID:15278511

Abstract

The ability of lidocaine to suppress activity of single vagal afferent fiber and that of phrenic nerve was studied in 20 cats anesthetized with pentobarbital. Slowly adapting stretch receptors (SAR, n = 16) and rapidly adapting stretch receptors (RAR, n = 7) were identified by their discharge pattern to pulmonary inflation. Intravenous lidocaine (1 mg.kg(-1) or 2 mg.kg(-1)) produced a suppression of SAR activity but not of RAR activity. Suppression of phrenic nerve activity lasted much longer than that of SAR. These findings indicate that iv lidocaine acts more dominantly on CNS than on peripherals. We conclude that iv lidocaine prevents cough and hemodynamic changes caused by airway manipulation mainly through its action on CNS and not on peripherals (peripheral nerves or their receptor).

摘要

在20只戊巴比妥麻醉的猫身上研究了利多卡因抑制单个迷走神经传入纤维和膈神经活动的能力。通过对肺充气的放电模式识别出慢适应性牵张感受器（SAR，n = 16）和快适应性牵张感受器（RAR，n = 7）。静脉注射利多卡因（1mg·kg⁻¹或2mg·kg⁻¹）可抑制SAR活动，但不抑制RAR活动。膈神经活动的抑制持续时间比利多卡因对SAR活动的抑制持续时间长得多。这些发现表明静脉注射利多卡因对中枢神经系统的作用比对周围组织的作用更显著。我们得出结论，静脉注射利多卡因主要通过其对中枢神经系统而非周围组织（周围神经或其感受器）的作用来预防气道操作引起的咳嗽和血流动力学变化。