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一些新型三环吡唑并[3,4-b]吲哚核苷的合成与抗病毒评价

Synthesis and antiviral evaluation of some novel tricyclic pyrazolo[3,4-b]indole nucleosides.

作者信息

Williams John D, Drach John C, Townsend Leroy B

机构信息

Department of Medicinal Chemistry, College of Pharmacy University of Michigan, Ann Arbor, Michigan 48109-1078, USA.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2004 May;23(5):805-12. doi: 10.1081/NCN-120039253.

DOI:10.1081/NCN-120039253
PMID:15281368
Abstract

Novel pyrazolo[3,4-b]indole nucleoside analogs were synthesized from the corresponding 3-formyl-2-chloroindole and 3-cyano-2-chloroindole nucleosides by treatment with hydrazine. Very few examples of pyrazolo[3,4-b]indole heterocycles have been published in the literature and this is the first synthesis of nucleoside analogs containing this heterocycle. These new pyrazolo[3,4-b]indole nucleosides were active against human cytomegalovirus and herpes simplex virus type 1, but this activity was not well separated from cytotoxicity.

摘要

新型吡唑并[3,4 - b]吲哚核苷类似物由相应的3 - 甲酰基 - 2 - 氯吲哚和3 - 氰基 - 2 - 氯吲哚核苷与肼反应合成。文献中报道的吡唑并[3,4 - b]吲哚杂环的实例极少，这是首次合成含有该杂环的核苷类似物。这些新型吡唑并[3,4 - b]吲哚核苷对人巨细胞病毒和1型单纯疱疹病毒具有活性，但这种活性与细胞毒性未能很好地区分开来。

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