使用自增强聚合物/生物活性玻璃棒固定兔股骨远端截骨术：一项实验研究

Fixation of distal femoral osteotomies with self-reinforced polymer/bioactive glass rods: an experimental study on rabbits.

作者信息

Pyhältö Tuomo, Lapinsuo Matti, Pätiälä Hannu, Pelto Mika, Törmälä Pertti, Rokkanen Pentti

机构信息

Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, PO Box 266 (Topeliuksenkatu 5), FIN-00029 HUS, Helsinki, Finland.

出版信息

Biomaterials. 2005 Feb;26(6):645-54. doi: 10.1016/j.biomaterials.2004.03.007.

DOI:10.1016/j.biomaterials.2004.03.007

PMID:15282142

Abstract

Two self-reinforced poly(desamino tyrosyl-tyrosine ethyl ester carbonate), poly(DTE carbonate) or self-reinforced poly(DTE carbonate)/bioactive glass rods, (2 mm by 40 mm) were implanted into the dorsal subcutaneous tissue and osteotomies of the distal femur were fixed with these rods (2 mm by 26 mm) in 36 rabbits. The follow-up times varied from three to 100 weeks. After sacrifice, three-point bending and shear tests and molecular weight measurements were performed for subcutaneously placed rods. Radiological, histological, histomorphometrical, microradiographic, and oxytetracycline-fluorescence studies of the osteotomized and intact control femora were performed. The initial mechanical properties were higher with the SR-poly(DTE carbonate) rods, but the SR-poly(DTE carbonate)/bioactive glass rods lost their mechanical properties slower. At 100 weeks the bending strength had decreased to 21% of the initial value with the SR-poly(DTE carbonate) rods and to 49% with the SR-poly(DTE carbonate)/bioactive glass rods. The shear strength had decreased to 10% with the SR-poly(DTE carbonate) rods and to 23% of the initial value with the SR-poly(DTE carbonate)/bioactive glass rods. Two slight displacements and one delayed union and one failure of fixation were seen in the SR-poly(DTE carbonate) group. In the SR-poly(DTE carbonate)/bioactive glass group five delayed unions and seven slight displacements were seen. No signs of osteolysis or foreign body reactions were observed. Signs of resorption of the implants were seen at 100 weeks in the SR-poly(DTE carbonate)/bioactive glass group. The present investigation showed that the mechanical strength and fixation properties of SR-poly(DTE carbonate) and SR-poly(DTE carbonate)/bioactive glass rods are suitable for fixation of cancellous bone osteotomies in rabbits.

摘要

将两根自增强聚（脱氨基酪氨酰 - 酪氨酸乙酯碳酸酯）（聚（DTE 碳酸酯））棒或自增强聚（DTE 碳酸酯）/生物活性玻璃棒（2 毫米×40 毫米）植入 36 只兔子的背部皮下组织，并使用这些棒（2 毫米×26 毫米）固定股骨远端的截骨术。随访时间从 3 周到 100 周不等。处死后，对皮下放置的棒进行三点弯曲和剪切试验以及分子量测量。对截骨和完整对照股骨进行放射学、组织学、组织形态计量学、显微放射学和土霉素荧光研究。自增强聚（DTE 碳酸酯）棒的初始机械性能较高，但自增强聚（DTE 碳酸酯）/生物活性玻璃棒的机械性能丧失较慢。在 100 周时，自增强聚（DTE 碳酸酯）棒的弯曲强度降至初始值的 21%，自增强聚（DTE 碳酸酯）/生物活性玻璃棒降至 49%。自增强聚（DTE 碳酸酯）棒的剪切强度降至 10%，自增强聚（DTE 碳酸酯）/生物活性玻璃棒降至初始值的 23%。在自增强聚（DTE 碳酸酯）组中观察到 2 例轻微移位、1 例延迟愈合和 1 例固定失败。在自增强聚（DTE 碳酸酯）/生物活性玻璃组中观察到 5 例延迟愈合和 7 例轻微移位。未观察到骨溶解或异物反应的迹象。在 100 周时，自增强聚（DTE 碳酸酯）/生物活性玻璃组中可见植入物吸收的迹象。本研究表明，自增强聚（DTE 碳酸酯）棒和自增强聚（DTE 碳酸酯）/生物活性玻璃棒的机械强度和固定性能适用于兔松质骨截骨术的固定。