吉西他滨联合持续输注5-氟尿嘧啶和大剂量亚叶酸钙治疗晚期胰腺癌。
Gemcitabine combined with infusional 5-fluorouracil and high-dose leucovorin for the treatment of advanced carcinoma of the pancreas.
作者信息
Oztop Ilhan, Yilmaz Ugur, Yavuzsen Tugba, Yaren Arzu, Tarhan Oktay, Sagol Ozgul, Coker Ahmet, Alakavuklar Mehmet
机构信息
Institute of Oncology, Faculty of Medicine, University of Dokuz Eylul, Izmir, Turkey.
出版信息
Chemotherapy. 2004 Jun;50(3):127-32. doi: 10.1159/000077886.
BACKGROUND
5-Fluorouracil (5-FU) and gemcitabine are the major active drugs in the treatment of pancreatic cancer.
METHODS
Twenty-two patients with advanced pancreas cancer were treated with a new chemotherapy regimen consisting of infusional 5-FU and high-dose leucovorin with gemcitabine (GEMFUFOL).
RESULTS
A total of 200 cycles of chemotherapy were administered. The response rate was 27.3%, all responses being partial. The median survival time and 1-year survival rate were, respectively, 13 months and 60.4%. The toxicity was very low and severe hematological toxicity was exceptional.
CONCLUSION
The GEMFUFOL regimen can be an active regimen for the treatment of advanced pancreatic cancer and has a low toxicity.
背景
5-氟尿嘧啶（5-FU）和吉西他滨是治疗胰腺癌的主要活性药物。
方法
22例晚期胰腺癌患者接受了一种新的化疗方案，该方案由静脉输注5-FU、高剂量亚叶酸钙和吉西他滨组成（GEMFUFOL）。
结果
共进行了200个化疗周期。缓解率为27.3%，所有缓解均为部分缓解。中位生存时间和1年生存率分别为13个月和60.4%。毒性非常低，严重血液学毒性罕见。
结论
GEMFUFOL方案可能是治疗晚期胰腺癌的一种有效方案，且毒性较低。
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