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[福尼尔坏疽:病例报告及近期文献综述]

[Fournier's gangrene: case report and review of recent literature].

作者信息

Geraci G, Pisello F, Lupo F, Cajozzo M, Sciumè C, Modica G

机构信息

Università degli Studi di Palermo, Dipartimento di Chirurgia Generale, d'Urgenza e dei Trapianti d'Organo, Sezione di Chirurgia Generale ad Indirizzo Toracico.

出版信息

Ann Ital Chir. 2004 Jan-Feb;75(1):97-106; discussion 106.

Abstract

OBJECTIVE

The authors report their experience in diagnosis and treatment of one case of Fournier's gangrene; recent international literature review.

EXPERIMENTAL DESIGN

Complete clinical report. Diagnostic, clinical and prognostic indication, evaluation of effectiveness of surgical treatment (debridement and necrosectomy) and follow-up; comparison between indications and multidisciplinary approach proposed by international literature.

SETTING

Operative Unit of General and Thoracic Surgery. University "Paolo Giaccone" of Palermo.

INTERVENTION

Repeated surgical treatment previous multimodal approach, according to international guide-lines.

RESULTS

Complete recovery with "restitutio ad integrum". No relapse were recorded at follow up.

CONCLUSIONS

Fournier's gangrene is an uncommon and aggressive synergistic fasciitis of the perineum and genital organs, which may bring the patient to death; it is a true surgical emergency. The disease can no longer be considered to be idiopathic; in most cases a urologic, colorectal or cutaneous source can be identified. Despite antibiotics and aggressive debridement, the mortality rate remains high, particularly in the elderly, in patients with renal failure, and in patients with extensive disease. The presentation is highly variable, necessitating a high index of suspicion. High risk patients include diabetics, alcoholics and debilitated and immunosuppressed individuals. As the AIDS population increases, the incidence of Fournier's gangrene may increase as well. In questionable cases, imaging modalities should be performed to allow early diagnosis and to reduce misses diagnosis. Broad spectrum antibiotics (while waiting for the results of culture and antibiogram effectuated on tissue specimens obtained during necrosectomy) and aggressive debridement remain the hallmarks of treatment. Hyperbaric oxygen therapy and improved local wound care may decrease the extent of tissue destruction. The surgical operation has to be performed in emergency to avoid a rapid spread of tissue necrosis and a possible development towards septic shock. Reconstructive techniques afford better cosmetic results. With early recognition, prompt treatment, improved wound care and reconstructive efforts, the mortality rates and cosmetic results should continue to improve.

摘要

目的

作者报告其诊治1例福尼尔坏疽的经验,并对近期国际文献进行综述。

实验设计

完整的临床报告。诊断、临床及预后指标,评估手术治疗(清创术和坏死组织切除术)的有效性及随访情况;将所采用的指标与国际文献提出的多学科方法进行比较。

地点

巴勒莫“保罗·贾科内”大学普通胸外科手术单元。

干预措施

根据国际指南,在多模式治疗前进行反复手术治疗。

结果

完全康复,恢复如初。随访期间未记录到复发情况。

结论

福尼尔坏疽是一种罕见且侵袭性强的会阴部和生殖器官协同性筋膜炎,可导致患者死亡,是一种真正的外科急症。该病不再被认为是特发性的;在大多数情况下,可以确定泌尿、结直肠或皮肤来源。尽管使用了抗生素并进行了积极的清创术,但死亡率仍然很高,尤其是在老年人、肾衰竭患者以及病情广泛的患者中。其表现差异很大,需要高度怀疑指数。高危患者包括糖尿病患者、酗酒者以及身体虚弱和免疫抑制的个体。随着艾滋病患者数量的增加,福尼尔坏疽的发病率可能也会上升。在可疑病例中,应进行影像学检查以便早期诊断并减少漏诊。广谱抗生素(在等待坏死组织切除术中获取的组织标本的培养和药敏试验结果期间)和积极的清创术仍然是治疗的关键。高压氧治疗和改善局部伤口护理可能会减少组织破坏的程度。必须在紧急情况下进行手术,以避免组织坏死迅速扩散以及可能发展为感染性休克。重建技术可提供更好的美容效果。通过早期识别、及时治疗、改善伤口护理和重建努力,死亡率和美容效果应该会继续改善。

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