丙型肝炎病毒相关边缘区淋巴瘤对抗病毒治疗的反应。

Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas.

作者信息

Kelaidi C, Rollot F, Park S, Tulliez M, Christoforov B, Calmus Y, Podevin P, Bouscary D, Sogni P, Blanche P, Dreyfus F

机构信息

1Department of Hematology, Hôpital Cochin, Université Paris V, Assistance Publique Hôpitaux de Paris, Paris, France.

出版信息

Leukemia. 2004 Oct;18(10):1711-6. doi: 10.1038/sj.leu.2403443.

DOI:10.1038/sj.leu.2403443

PMID:15284859

Abstract

A link between chronic hepatitis C virus (HCV) infection and low-grade B-cell lymphomas has been suggested by epidemiological studies. Marginal zone lymphomas (MZLs) including splenic lymphomas with villous lymphocytes are among the most frequently reported subgroups in the setting of chronic HCV infection. In this study, we examined the effect of antiviral treatment in eight patients with HCV-associated MZL. We found that five out of eight patients have responded to interferon alpha and ribavirin. In some cases, hematologic responses were correlated to virologic responses. In addition, we report a case of large granular lymphocyte leukemia occurring in association with MZL and HCV, and responding to interferon and ribavirin. We suggest that there is an etiologic link between HCV and antigen-driven lymphoproliferative disorders.

摘要

流行病学研究表明，慢性丙型肝炎病毒（HCV）感染与低度B细胞淋巴瘤之间存在关联。边缘区淋巴瘤（MZLs），包括伴有绒毛状淋巴细胞的脾淋巴瘤，是慢性HCV感染情况下最常报告的亚组之一。在本研究中，我们检测了抗病毒治疗对8例HCV相关MZL患者的疗效。我们发现，8例患者中有5例对α干扰素和利巴韦林有反应。在某些情况下，血液学反应与病毒学反应相关。此外，我们报告了1例与MZL和HCV相关的大颗粒淋巴细胞白血病患者，其对干扰素和利巴韦林有反应。我们认为HCV与抗原驱动的淋巴增殖性疾病之间存在病因学联系。